Publish Time: 2020-06-11 Origin: Site
The potential treatment for Alzheimer's disease may be in your kitchen. Curcumin, a natural product in spice turmeric, has been used in Asian countries for centuries; recently, an article published in the international In a research paper in the journal Journal of Alzheimer's Disease, researchers from Vanderbilt University Medical Center stated that a chemical analog close to curcumin may be used for the treatment of brain diseases.
Researcher Wellington Pham said that curcumin can enter the brain, bind to and destroy the amyloid beta plaques present in the brain of Alzheimer's patients, and it has low toxicity. The accumulation and worsening of amyloid plaques is the main reason for the death and loss of neurons in Alzheimer's disease patients; therefore, the development of a small molecule to reduce and destroy the accumulation of amyloid plaques in the brain will be the treatment of Al The best choice for Zheimer's disease.
[2] JBC: Curcumin can prevent Parkinson's disease
Curcumin is a major compound in the Asian spice turmeric and may be used to cure Parkinson's disease in the future. According to researchers at Michigan State University, this particular substance can prevent the aggregation of proteins associated with Parkinson's disease pathology. Parkinson's disease is a degenerative disease of the central nervous system, which is mainly characterized by the formation and activity of dopamine. In addition, patients also have the presence of Lewy Bodies. Lewy body is a pathological sign of Parkinson's disease, which can be found in degenerative cells in substantia nigra cells.
A research team led by Basir Ahmad, a postdoctoral researcher at Michigan State University, discovered earlier this year that Lewy bodies are mainly present in neurons formed by the accumulation and aggregation of α-synuclein.
The new research led by Ahmal shows that curcumin binds to α-synuclein, thereby preventing its aggregation in neurons. Lisa Lapidus, associate professor of physics at Michigan State University, said: "Our research shows that curcumin can relieve protein aggregation, more specifically, curcumin can bind α-synuclein well and prevent α-synuclein. Gathering."
[3] PLoS ONE: Curcumin may be developed into a drug for Alzheimer's disease
Early studies have shown that curcumin, the main component of turmeric, can improve the mobility of fruit flies with neurological symptoms similar to Alzheimer's disease (senile dementia), thereby extending the lifespan of fruit flies. Related research results have been published in the international authoritative journal PLoS One. In this study, the researchers found that curcumin is mainly in the early stages of the disease, by inhibiting the fibrous structure and amyloid fibrous fragments that are toxic to neurons The role of the formation.
Since then, curcumin has been studied as a potential drug to treat Alzheimer's disease. The pathogenesis of Alzheimer's disease is mainly the accumulation of viscous amyloid and taurine protein fibers.
Recently, a study conducted by researchers from Linkoping University explored how curcumin affects Alzheimer's-like neurological disorders in transgenic fruit flies, hoping to find curcumin to treat Alzheimer's The exact target of the disease's efficacy.
[4] Curcumin-containing drugs help brain cells regenerate in patients with stroke
Research conducted by American researchers on animals has shown that a mixed drug containing turmeric chemistry can help brain cells in stroke patients regenerate.
It is understood that this drug is made with curcumin.
Curcumin is a substance extracted from turmeric rhizomes. In South Asian or Middle Eastern cuisine, this spice is very common, especially curry.
Lapchak, a scientist at Cedars-Sinai Medical Center, said the drug can repair nerve bundles that supply neurons with nutrients. The researchers plan to start human trials soon.
Studies have shown that although this new drug cannot eliminate blood clots, it can "slow down the movement disorder caused by stroke" within 1 hour after being applied to rabbits, and the conversion time for humans is 3 hours.
[5] Curcumin can help extend life
Preliminary experimental results show that curcumin contains a variety of anti-inflammatory, anti-oxidant and anti-cancer ingredients, which can affect the genes that cause aging in fruit flies.
A new study in the United States found that curcumin can play a role in prolonging animal life, because this substance is rich in antioxidants and other chemical ingredients that are beneficial to the body.
Researchers at the University of California, Irvine reported in the new issue of "Anti-Aging Research" that they conducted research on fruit flies. It was found that if flies regularly eat curcumin, their lifespan can be extended by 20%, and their activities are more flexible and less prone to cancer.
The head of the research, Mahtab Jafari, said that preliminary experimental results show that curcumin contains a variety of anti-inflammatory, anti-oxidant and anti-cancer ingredients that can affect the genes that cause aging in fruit flies.
[6] Using turmeric to discover the phenomenon of prolonging life and controlling aging
The Korea Institute of Biotechnology published turmeric to curb aging, and discovered the fact that the genetic genes that promote aging are reduced using fruit flies.
Turmeric is a spicy material with spicy and bitter taste, and is the main raw material of curry. According to the test results, the average lifespan of drosophila flies sucked by turmeric is increased by about 20% compared to the flies that are not ingested. The degree of aging and regression is also very low. At the same time, there is a phenomenon of prolonging healthy life.
At the same time, Drosophila ingesting turmeric is more resistant to stress in various environments than Drosophila not ingesting, and it was found that Drosophila ingesting turmeric not only found changes in genetic genes related to aging, but also prolonged lifespan.
Dr. Li Guishan said: "The research on curbing aging using turmeric can be applied to some applications of new drug development similar to the production of anti-aging agents using turmeric. In Korea, which has entered an aging society, it can be given to the elderly to the health and longevity. help".
In addition, the results of this study will be published in the August edition of the online edition of Rejuvenation Research, an international academic journal in the field of aging biology. This research was the result of a joint study by Professor Min Jingzhen of Inha University and Professor Jafari of California State University.