Views:7 Author:Site Editor Publish Time: 2020-06-10 Origin:Site
Curcumin is a chemical component extracted from the rhizomes of some plants in the family Zingiberaceae and Araceae. Among them, turmeric contains about 3% to 6%. It is a rare diketone pigment in the plant kingdom and is a diketone. Studies have shown that curcumin has the effects of lowering blood fat, anti-tumor, anti-inflammatory, choleretic, and anti-oxidant.
Researchers from Curtin University said curcumin, a compound found in turmeric root, can effectively treat most cancers and other inflammatory-induced diseases. This review article analyzes many past clinical trials. Related clinical studies have used curcumin to treat cancer patients, and found that curcumin is a safe and effective molecule for treating cancer.
Researcher Gautam Sethi said that most diseases, including cancer, are caused by abnormal regulation of multiple genes, so in order to treat cancer, multiple targeting agents are required, unlike the use of a single cancer target in the past. To the preparation. Multi-targeted preparations can target a variety of uncontrolled oncogenic cascade signals, and at the same time, they can effectively treat cancer, and many genes are often mutated during cancer development.
 PLoS ONE: Curcumin inhibits colon cancer metastasis
A new scientific study has identified curcumin (a biologically active molecule derived from spice turmeric), one of the mechanisms for preventing colon cancer cell metastasis. The study found that curcumin can block the colon cancer protein, cortical protein. Cortical proteins are essential proteins for the movement of cancer cells, and they are often overexpressed in cancer, thereby prompting cancer cells to metastasize to other organs in the body.
Curcumin is the active ingredient of turmeric and has been used in the treatment of many types of cancer by scientific research. Curcumin has been shown to have a chemopreventive effect on cancer, which can reverse, inhibit or prevent the ability of cancer to develop. New research has discovered one of the mechanisms by which curcumin prevents colon cancer cell metastasis. The team found that the activated part of cortical protein, pTyr421, is over-activated in colon malignancies. We found that the excessive activation of cortical proteins is caused by the process of hyperphosphorylation.
 Org Biomol Chem: remove its dross and take its essence-curcumin and thalidomide combine to kill cancer cells
Based on the structural characteristics of the anti-nausea drug thalidomide, researchers at the Federal University of Virginia Massey Cancer Center mixed thalidomide with the turmeric spice commonly used in the kitchen to create some new hybrid molecules. Of molecular compounds can effectively kill multiple myeloma cells. The research paper was published in the recently published Journal of Organic & Biomolecular Chemistry.
As early as the 1950s, thalidomide was used as an anti-nausea drug to help control morning sickness, but it was later removed because it was found in 1962 to cause birth defects.
In the late 1990s, thalidomide returned to the stage of history as a single or combined treatment for multiple myeloma. Turmeric is an ancient spice grown in India and other tropical regions of Asia. It has a long history of use and has recently been used as an agent to prevent and treat cancer, arthritis, and Alzheimer's disease.
 Curcumin may inhibit prostate cancer metastasis
We often use turmeric powder (Powdered turmeric) to treat osteoarthritis and other diseases, its active ingredient curcumin can effectively inhibit the inflammatory response. Recently, researchers from Ludwig Maximilian University revealed that curcumin can effectively inhibit the formation of cancer metastases. Related research results were published in the international journal Carcinogenesis.
Prostate cancer is a malignant tumor that is widespread in Western countries. It is usually diagnosed after the patient has metastasized. Now researchers have begun to study curcumin to inhibit the formation of cancer metastases. First, the researchers examined the molecular processes involved in abnormal regulation in prostate cancer cells. Breast cancer and prostate cancer are usually associated with underlying or chronic inflammatory responses. In many cases, tumor cells can produce proinflammatory immune modulators, including CXCL1 and CXCL2.
 Mol Biol Rep: Curcumin inhibits NF-κB signaling pathway against breast cancer metastasis
Curcumin is a chemical component extracted from the rhizomes of some plants in the family Zingiberaceae and Araceae. Among them, turmeric contains about 3% to 6%. It is a rare diketone pigment in the plant kingdom and is a diketone. Compound.
Recently, it has been reported that curcumin has an anti-cancer effect on many types of cancer, but the molecular mechanism of this anti-cancer effect is not fully understood. In a recent study published in Molecular Biology Reports, the researchers evaluated the effect of curcumin on human breast epithelial cells MCF-7 cells. After the cells were treated with curcumin, MTT assay was used to detect tumor cell viability. Transwell cells were used to detect the invasive ability of cells. The activity of NF-κB binding DNA was used to detect nuclear extracts using an ELISA kit across AM NF-κB. Western blotting was used to detect the effect of curcumin on uPA expression.
 PLoS One: Curcumin's anti-small cell lung cancer mechanism
Turmeric (Curcuma longa) is the rhizome of turmeric in the ginger family. Turmeric is not only used as a spice in food curries in India, but also has a long history of medicinal use in China. Pain relief. Curcumin, the main component of turmeric, has a wide range of pharmacological effects, and the research on curcumin's anti-tumor effect has long been concentrated on the chemoprevention of tumors. With the continuous development of modern molecular biology research, researchers have conducted in-depth research on the mechanism of action of curcumin.
Although a large number of documents have confirmed that curcumin can prevent cancer and inhibit tumor development. However, few people know the specific mechanism of curcumin's anti-small cell lung cancer (SCLC). A recent study published in the journal PLoS One confirmed that curcumin can inhibit the expression of STAT3, thereby inhibiting the proliferation of small cell lung cancer cells, affecting the cell cycle of tumor cells, and reducing cell migration, invasion and angiogenesis.
After treatment with 15μmol/L curcumin, small cell lung cancer cells can effectively inhibit the phosphorylation of STAT3 and down-regulate the downstream regulatory proteins of STAT3, which helps to inhibit cell proliferation, weaken the ability of cell colony formation, cell migration and invasion Ability is also reduced.
 Cancer Res: Curcumin can inhibit the growth of prostate cancer cells
Prostate cancer is a malignant tumor that occurs in male prostate tissue and is the result of abnormal disordered growth of prostate acinar cells. The incidence of prostate cancer has obvious geographical and ethnic differences. In developed countries and regions such as Europe and the United States, it is the most common malignant tumor in men, and its mortality rate ranks second among various cancers. In Asia, its incidence rate is lower than that of Western countries, but it has shown a rapid upward trend in recent years.
Androgen receptors play an important role in the development of prostate cancer. The main target of castration therapy (ADT) is to inhibit androgen receptors in patients with prostate cancer. However, the clinical treatment often ends in failure. The main reason is that the androgen receptor in the receptor of prostate cancer patients is activated again. During the treatment of ADT, due to the presence of p300 and CPB, prostate cancer cells can remain active and survive.
Recently, a preclinical study on curcumin in curry published in Cancer Research confirmed that curcumin has the effect of inhibiting tumor growth in the androgen deprivation treatment of prostate cancer patients who have failed castration treatment.
 Acta Pharmacol Sin: Curcumin can improve the efficacy of breast cancer
Curcumin is a natural active ingredient extracted from the rhizomes of turmeric, curcuma, turmeric and other ginger plants. Its tumor effect was first proposed by the Indian scholar Kuttan in 1985. In recent years, curcumin has produced, The mechanism of inhibition of proliferation and metastasis was discovered. The National Cancer Institute listed it as a third-generation cancer treatment.
On November 29, the Journal of Chinese Pharmacology (Acta Pharmacologica Sinica) published the research paper "Curcumin enhanced antiproliferative effect of mitomycin C in human breast cancer MCF-7 cells in vitro and in vivo" ", the research group found that curcumin and mitomycin C synergistic effect can improve the effect of mitomycin C treatment of breast cancer.
Su Shibing pointed out that breast cancer, the malignant tumor with the highest incidence in women, still lacks ideal therapeutic drugs. The chemotherapeutic drugs used clinically are mainly mitomycin, etc., but these chemically synthesized drugs have large side effects, affect the quality of life, and are prone to drug resistance. Therefore, finding a drug that can "enhance efficacy and reduce toxicity" has become a research hotspot.
 American experts say curcumin can inhibit cancer cells
American researchers announced that curcumin, which makes the curry powder yellow, may help treat skin cancer. Bharat Agarwal and his colleagues at the Department of Experimental Therapy, Anderson Cancer Hospital, University of Texas, and his colleagues used three different doses and different times of curcumin to test three batches of melanoma cells. Experimental results show that the curcumin found in the condiment turmeric can make melanoma skin cancer cells more likely to self-destruct. The researchers found that curcumin helps prevent breast cancer tumor cells from spreading into the lungs of mice. Curcumin inhibits two proteins that keep tumor cells from dying.
 BJC: Turmeric can induce apoptosis in cancer cells
Curry is a mixture of spices. The reason it has the effect of killing cancer cells is mainly due to the curcumin contained in the turmeric in its ingredients. In most cases, the way to make cancer cells die is by activating cysteine proteases (also known as apoptotic proteases) in the cells, thereby initiating the apoptosis of the cancer cells themselves.
Geraldine O'Sullivancoin, a researcher at the Cork Cancer Research Centre in Ireland, and his research team found that curcumin-treated cancer cells began to die within 24 hours, and the level of cysteine protease was not No improvement. Not only that, even if the researchers used other drugs to prevent the cysteine protease from initiating programmed apoptosis, the cancer cells would still die. This shows that curcumin can kill cancer cells through another completely new way.