Views: 11 Author: Site Editor Publish Time: 2020-11-09 Origin: Site
Modern research has found that senna has pharmacological effects such as diarrhea, antibacterial, hemostasis, and spasmolysis. In recent years, it has been mainly used at home and abroad to prepare for intestinal cleaning before various imaging examinations of the abdomen and intestines or before surgery. It is mainly used to treat various constipation, especially senile and intractable constipation. It is also useful for recovery of bowel function after abdominal surgery. enhancement. It can also be used for upper gastrointestinal bleeding, cholecystitis, and acute pancreatitis. It is the most widely used cathartic in the world. But its adverse reactions are also increasing day by day.
(1) Pharmacological effects
1. Purgative effect
Senna contains anthrone derivatives, and its laxative effect and irritation are stronger than other laxatives containing anthraquinones, so it may be accompanied by abdominal pain when diarrhea. Its active ingredients are mainly sennosides A and B. After being absorbed by the stomach and small intestine, they are decomposed in the liver. The decomposition products pass through the blood and excite the bone marrow ganglia to contract the large intestine, causing diarrhea. The effect of senna is extensive and strong. and
It is considered that it is more suitable for acute constipation than for chronic patients.
Senna plants can produce many economically valuable compounds. In addition to purgative effects, certain senna leaves also have antibacterial, antibiotic and detoxifying effects. The water infusion of senna has an inhibitory effect on dermatophytes such as Odurian Spores and Nocardia stellaria in the test tube.
The alcohol extract of Senna leaf has antibacterial effect on a variety of bacteria (Staphylococcus and Diphtheria bacillus, Typhoid bacillus, Paratyphoid bacillus, Escherichia coli). Its water extract is only effective against typhoid bacilli. The seeds of Auricularia senna can lower the fasting blood sugar of dogs, and the whole herb also contains cardiac glycosides.
3. Hemostatic effect
Effective for stomach and duodenal bleeding. Use this product's water immersion liquid to spray on the gastric bleeding under the gastroscope, and the immediate hemostasis effect can be seen directly. Intraperitoneal injection of 200 mg/kg of total senna glycosides can significantly shorten the bleeding time of mice. Oral senna leaves can increase the number of platelets and fibrinogen content, and shorten the clotting time, thromboplastin time, plasma recalcification time and blood clot contraction time. In addition, the protective effect of this product on gastric mucosal damage in rats caused by hydrochloric acid and indomethacin is also beneficial to the prevention and treatment of gastric and duodenal bleeding.
4. Muscle relaxation
It can block the impulse transmission at the nerve-muscle junction and relax the striated muscle. Senna can resist the smooth muscle spasm caused by acetylcholine and gradually restore the normal peristalsis of the bowel.
5. About cleaning the intestines
Radiologists like plain radiographs of the abdomen, colon and pyelography, and before surgical abdominal operations, they all like to use senna to clean the intestines, which is also convenient for patients. Even if the cleaning is not ideal enough, you can still clean the enema. After more than 80 years of practice, it has been gradually promoted.
6. Lose weight
Senna leaves are used to make slimming tea, either single or compound. The color and fragrance are more suitable and delicious. It has been on the market for more than 10 years and has a certain effect. However, there are abdominal pain and diarrhea reactions, drug resistance, and its effect has certain limitations.
7. Reducing heat conductivity
Senna leaves are bitter and cold in nature, sticky and smooth in texture, can enter the large intestine, reduce heat accumulation, moisturize dry intestines, relieve stool, and help digestion when used sparingly, so it is suitable for heat accumulation or constipation due to food accumulation, and abdominal distension .
8. Water swelling
It is mostly caused by emotional depression, improper diet, excessive alcoholism, long-term worm accumulation, liver and spleen damage, stagnation of qi and blood, and lack of moisture. Symptoms can be seen in the abdomen swelling, the green tendons of the belly skin are exposed, and the limbs are not swollen (or slightly swollen). This card can use senna leaf to relieve swelling.
9. Identify applications
Rhubarb tends to be cold, croton tends to be hot, and senna is between the two. But the amount of dosage is related to the urgency of the next dose. Soaking takes the lower speed, while the decoction is slower.