Views: 1 Author: Site Editor Publish Time: 2021-08-13 Origin: Site
Curcumin is mainly derived from the traditional Chinese medicine turmeric. Turmeric has the functions of breaking blood, promoting qi, clearing menstruation and relieving pain. Curcumin is its main functional component. Modern scientific research has shown that curcumin has anti-cancer, anti-inflammatory, and antioxidant functions. A multi-potent natural active substance.
Curcumin has an inhibitory effect on a variety of tumors, such as liver cancer, stomach cancer, colorectal cancer, esophageal cancer, breast cancer, prostate cancer, skin cancer, lymphoma and leukemia. It can affect multiple links and steps of tumor occurrence and development, such as inducing tumor cell apoptosis, inhibiting oncogene expression, resisting tumor invasion and metastasis, inhibiting tumor angiogenesis, and increasing the sensitivity of tumor cells to chemotherapy, so as to exert resistance Cancer effect.
Curcumin can improve the symptoms of rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, myocarditis, systemic lupus erythematosus and other diseases. The effect is mainly through the inhibition of inflammatory mediators such as cyclooxygenase, lipoxygenase, tumor necrosis factor alpha, interferon gamma, inducible NO synthase, and transcription factors such as nuclear transcription factor kB and activator protein-1.
Curcumin is a unique antioxidant with many functional groups. From the analysis of chemical structure, curcumin has two phenylacrylic skeletons like cinnamaldehyde, and each of the two benzene rings has a phenolic hydroxyl group and a methoxy group. The group is connected to a β-diketone/enol structure. Many studies have confirmed that phenolic substances with 1,2-dihydroxyl groups have strong antioxidant activity, because such compounds produce quinones with good stability during the antioxidant process. Whether it is the phenolic group or the methyl hydrogen in the center plays a role in the antioxidant function of curcumin, there is no conclusion yet.
Flavin can prevent oxidation and scavenging free radicals, anti-inflammatory reactions, anticoagulation, lipid regulation, anti-lipid peroxidation, inhibition of plaque formation, inhibition of vascular smooth muscle cell proliferation, and induction of heme oxygenase-1 expression. The role of atherosclerosis.
Studies have found that curcumin has anti-HIV effects. The evolution of HIV infection and the development of immunodeficiency are related to the activation of the latent provirus, and the replication of the provirus is controlled by the long terminal repeat (LTR) of the virus. LTR regulatory factors may be the basis for the transcriptional activation of HIV-1 latent provirus through many activating factors. Curcumin inhibits HIV-LTR activity and viral replication in chronic HIV-1 infection, suggesting that curcumin has an effect on viruses in a proviral state. Curcumin may directly or indirectly affect HIV-1 LTR activity regulators. It is speculated that curcumin used in the treatment of HIV-infected patients can increase the body's humoral immune function and prevent secondary infections, but it has no effect on cellular immune function.
Curcumin has an inhibitory effect on liver lipid peroxidation and the increase of serum AST and ALT activities caused by carbon tetrachloride, showing a dose-effect relationship, and prevents liver morphology changes, and can also significantly inhibit liver lipids caused by Co ray Peroxidation level. Reddy et al. reported that curcumin was used for 10 days to protect the liver and effectively reverse the liver damage induced by aflatoxin. Curcumin is widely used in Indian medicine as an effective treatment for liver disease and infectious fever. Experiments have shown that curcumin can promote the flow of bile in rats. Curcumin is mainly metabolized in the liver after oral absorption, so it is a good protective agent for liver toxicity damage.
In addition to the above effects, curcumin also has many pharmacological effects such as protecting the liver, anti-gastric and duodenal ulcers, anti-fibrosis, promoting immune activity, inhibiting skin mutations induced by ultraviolet light, lowering blood sugar, and killing nematodes.