Views: 11 Author: Site Editor Publish Time: 2023-05-06 Origin: Site
Hypericum perforatum extract also known as St. John's wort extract is made from dried Hypericum perforatum flowering stage or aerial parts, using methanol as the extraction solvent and is obtained through extraction, filtration, crystallization, purification and other processes.It is in the form of dark brown or tan powder, with a bitter taste, and its main ingredient is hypericin and its derivatives. Hypericum perforatum extract is mainly used in the field of medicine and health care products manufacturing.
Hypericum perforatum for anti-depression first started in Germany.In the early 19th century, German doctor Kemer discovered that Hypericum perforatum could treat emotional disorders. Since then,Hypericum perforatum has long been used as a treatment for skin surface wounds and an antidepressant in Europe.Especially since the 1980s, the ingredients of Hypericum perforatum have become more and more research hotspots for foreign medical workers, and the most convincing one is the drug containing hypericin in the treatment of mild and moderate depression patients.The treatment effect of Hypericum perforatum extract is significantly better than placebo, and compared with standard antidepressant drugs (tricyclics), the efficacy and side effects are small.
AIDS is a persistent disease that threatens human health, and its causative factor is HIV.As early as the 1980s, Memel et al reported the anti-HIV reverse transcriptase effect of hypericin:Hypericin 2 ug/rnl was cultured with HIV, and the results showed that the HIV reverse transcriptase activity was reduced by 75%.De-clervp believes that the anti-HIV mechanism of hypericin may be to inhibit reverse transcriptase, and hypericin does not affect the transcription and translation of the virus, but interferes with the virus,studied the interaction between hypericin and HIV virus reverse transcriptase at the molecular level to explore the antiviral mechanism of hypericin compounds, and their research can provide a theoretical model for the drug design of HIV virus inhibitors and important references.In addition to its certain effects on AIDS, hypericin has been reported to have certain antiviral effects on enveloped viruses, hepatitis B and hepatitis C viruses, etc.
The total extract of Hypericum perforatum has strong antibacterial and bactericidal effects on 11 Gram-positive bacterial strains that are resistant to commonly used antibiotics isolated clinically, suggesting that the extract can be used to control clinically resistant to various antibiotics.Infections caused by drug-resistant Gram-positive strains.
4.Anti-tumor and anti-cancer effects
Hyperforin can inhibit the growth of MT-450 breast cancer cells, and the mechanism may be that hyperforin activates the mitochondria-mediated signal transduction pathway, thereby inducing tumor cell apoptosis.Hypericin has inhibitory effect on the growth of leukemia cell lines K562 and U937 and malignant glioma cell line LN229, and confirmed the synergistic effect of hypericin and hypericin in inhibiting the growth of K562 and U937 cells.