Views: 3 Author: Site Editor Publish Time: 2022-08-26 Origin: Site
Shikimic acid is an organic compound with the molecular formula c7h10o5. It is colorless or white needle like crystal. The solubility in water at 20 ℃ is 18%, slightly soluble in ethanol and ether, almost insoluble in chloroform and benzene. Shikimic acid can inhibit platelet aggregation, arteriovenous thrombosis and cerebral thrombosis by affecting the metabolism of arachidonic acid. Shikimic acid has anti-inflammatory and analgesic effects, and can also be used as an intermediate of antiviral and anticancer drugs. This product is mainly used as pharmaceutical intermediate and has certain irritation, so it is not suitable for direct use . It is a dry and mature fruit naturally existing in the Magnoliaceae plants such as Illicium verum Hook. F.
Shikimic acid has anti-inflammatory and analgesic effects. Shikimic acid can also be used as an intermediate of antiviral and anticancer drugs.
Pharmacological action: shikimic acid is a monomer compound extracted from star anise, which has anti-inflammatory and analgesic effects and is an intermediate of anticancer drugs. Shikimic acid can inhibit platelet aggregation, venous thrombosis and cerebral thrombosis by affecting the metabolism of arachidonic acid. Shikimic acid has anti-inflammatory and analgesic effects, and can also be used as an intermediate of antiviral and anticancer drugs.
Star anise contains shikimic acid, an important component against Asian avian influenza virus. Experts say this is the only weapon in the world to deal with bird flu. It is rich in China and Vietnam. It is the fruit of a small Oriental tree species of Magnoliaceae. It tastes spicy and similar to liquorice. It is the traditional seasoning of Oriental cooking and the main spice of liqueur such as French Green fennel wine and fennel liqueur. It can also be used to increase the flavor of sweets, anise wine and tobacco. The medicinal value of star anise has been concerned before the arrival of avian influenza, including its possible anticancer effect. As the main source of shikimic acid, star anise has again attracted attention because shikimic acid is an important component of the drug Tamiflu, which can effectively deal with the deadly H5N1 avian influenza virus. "It takes 10 capsules of Tamiflu to treat a patient infected with avian influenza, and 13 grams of star anise to make 10 capsules of Tamiflu," said Albert ergrisi, director of ricca, a maker of fennel wine in Marseille, France The price of shikimic acid is between 200-250 dollars per kilogram, and the price of shikimic acid is as high as 50 dollars per gram.
The preliminary study of the Pharmacology Laboratory of Beijing University of traditional Chinese Medicine found for the first time that shikimic acid has an obvious antithrombotic effect and can inhibit the formation of brake, venous thrombosis and cerebral thrombosis. In order to clarify its antithrombotic mechanism, researchers studied the effect of shikimic acid on platelet aggregation and coagulation, and analyzed the relationship between its mechanism of action and arachidonic acid metabolism. The results suggest that shikimic acid may play an antithrombotic role by affecting the metabolism of arachidonic acid, inhibiting platelet aggregation and inhibiting the coagulation system. Huang Jianmei, an associate professor of Beijing University of traditional Chinese medicine, is an expert in the study of Illicium plants. In the face of the reporter's interview, Huang Jianmei said that shikimic acid is a very common thing. If it was not for the avian flu, and if it was not for the shikimic acid extracted from octagonum by Roche's special anti avian flu drug "Tamiflu", no one would ever pay attention to shikimic acid, and no one would realize that octagonum was originally a traditional Chinese medicine.