Views: 3 Author: Site Editor Publish Time: 2022-07-11 Origin: Site
Senna glycoside a+b is the main functional component of senna extract, but its characteristics of thermal decomposition have caused great obstacles to mass production. The vast majority of senna extract on the market is dried in sheds, and its temperature is greater than 120 ℃, resulting in the decomposition loss of senna glycoside a+b, and its actual content simply cannot reach the declared content.
Senna glycosides are the main purgative components in senna leaves, and Senna glycosides with relatively high content in senna leaves are a, B, C and D. Due to the similar physical and chemical properties and activities of the four Senna glycosides, the early content determination methods used total Senna glycosides as an index to evaluate the quality of senna extract.
Senna glycoside is formed by the interconnection of two molecules of anthrone C-C. it is extremely unstable in the extraction process, and it is very easy to decompose in the presence of light, heat, acid and alkali, resulting in the loss of all content when it is slightly ignored in the later purification and separation. Solving the problem of its heat sensitivity has become a difficulty in the large-scale production process. According to the data of Xi'an xuhuang Biotechnology Co., Ltd. in the production process research and development, when the temperature is higher than 60 ℃, the content loss rate reaches more than 90%. Since steam heating, vacuum oven or spray drying tower are widely used in the process of plant extracts, the temperature cannot be below 60 ℃. After dozens of equipment improvements and process attempts, the company finally made a process suitable for the harsh conditions of the product production.
The testing center of Xi'an xuhuang Biotechnology Co., Ltd. sampled and analyzed most of the senna leaf extracts sold on the market. The results showed that the content of senna glycoside a+b HPLC was less than 1% when the extraction, concentration, powder spraying and drying process was adopted. Among dozens of samples tested, the content of only one sample is consistent with the marked content, and the HPLC result is greater than 8%. The analysis shows that its content is mainly lost in the process of concentration and powder spraying. The temperature of powder spraying is more than 120 ℃, which is far beyond the tolerable temperature of senna glycosides.
Xi'an xuhuang Biotechnology Co., Ltd. Senna raw materials are imported directly from India.