Views: 2 Author: Site Editor Publish Time: 2022-08-17 Origin: Site
Glutathione is an inborn substance in the human body. The content of glutathione in the body is the highest in the infant period and decreases with the age. In nature, it mainly exists in animal liver, yeast, muscle and blood cells, and some plants also contain high glutathione, such as tomatoes, cherries, virgin fruits (commonly known as small tomatoes).
Glutathione is a tripeptide composed of glutamic acid, cystine and glycine. It is a physiological factor with extensive physiological effects, called GSH for short. It is also the collective name of glutathione + sulfhydryl sh. Like some whitening substances, such as tranexamic acid, it is mainly used for non whitening in the early stage of the clinic. The core role of glutathione in the clinic is detoxification, so it has a significant role in purifying the internal organs, such as repairing liver and kidney damage and eliminating heavy metals in the body. Subsequently, it was found that glutathione can whiten skin and improve skin quality. As for how glutathione is achieved. We still have to start with the mechanism of aging and blackening of human skin.
An important cause of skin aging is free radicals
Under normal circumstances, our body can balance free radicals, a little troublemaker. However, with the deterioration of our living environment, we also have to stay up late, drink alcohol, smoke and constant pressure. The free radicals in the human body become more and more, and the more electrons are robbed, the more unstable the other half of the electrons are lost. Thus, you left one after another color spots, plaques and so on on your face, and your face began to wrinkle, become loose and dull.
There are some free radical scavenging and antioxidant substances in our body, including superoxide dismutase (SOD), catalase, glutathione peroxidase and other enzymes, vitamin C, vitamin E, reduced glutathione, carotene and active selenium.
Glutathione can purify the internal environment, remove free radicals, and delay skin aging. So how does it achieve the whitening effect?
When the sun shines on the body, it stimulates a series of chain reactions, in which tyrosine is converted into DOPA under the action of tyrosinase, which is the first decisive step in melanin synthesis. Tyrosine is an essential amino acid for physiological activities, and it exists widely in human body. Tyrosinase activity in darker skin is about three times that in lighter skin. To control skin melanization, we can find ways to block the role of tyrosinase.
Because the amount of melanin synthesis is positively related to the activity of tyrosinase, blocking tyrosinase has become the key to prevent melanin. The components that can inhibit tyrosinase activity include resveratrol, kojic acid, arbutin, azelaic acid, hemostatic cyclic acid, etc., with slightly different mechanisms of action.
Cysteine in glutathione has such a function. It has been found in medical experiments that cysteine can reduce the activity of tyrosinase. Cysteine is an amino acid containing sulfhydryl. Sulfhydryl has strong nucleophilic effect. Sulfhydryl can react with DOPA quinone quickly to form a colorless Doba derivative, thus blocking the transformation of DOPA to pigment.
Daily skin care and maintenance to prevent skin aging and deterioration, the first task is to stay up less late and reasonably arrange the work and rest time. In addition, the body needs to supplement antioxidants to remove free radicals. Of course, sun protection is also the first task to maintain the skin white and flawless, and avoid the skin darkening and color spots aggravating due to ultraviolet radiation.