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Views: 3 Author: Site Editor Publish Time: 2021-09-22 Origin: Site
Chrysin is also known as white poplar. Pale yellow prismatic crystals (crystallized from methanol), melting point 285°C. It is soluble in alkali hydroxide solution, slightly soluble in ether, ethanol and chloroform, and insoluble in water. It exists in the seeds and stem bark of the bignoniaceae wood butterfly, the heartwood of the Pinus sylvestris, the heartwood of the Miscanthus pine, etc. It is toxic to certain cancer cells.
(1) Anti-tumor cell proliferation
(2) Induce tumor cell apoptosis
(3) Reversal of multidrug resistance of tumor cells
(4) Anti-gene mutation effect: Anti-tumor effect and mechanism of common chrysin derivatives
(1) Chrysin inhibits platelet aggregation induced by ADP, collagen, thrombin and U46619.
(2) Chrysin inhibits collagen-induced platelet activation and granule release.
(3) Chrysin inhibits the adhesion number of platelets on solidified collagen and reduces the expansion area of a single platelet. Chrysin reduces the expansion of platelets on solidified fibrinogen.
(4) Western blot analysis showed that chrysin inhibits the phosphorylation of PLCY2 and reduces the activity of PKC. At the same time, chrysin inhibits Akt phosphorylation and ERK1/2 phosphorylation in the MAPK pathway. PI3K broad-spectrum inhibitor LY294002 combined with chrysin enhances the inhibition of platelet aggregation.
