Publish Time: 2022-08-12 Origin: Site
N-Acetylneuraminic acid is a derivative of 9-carbon monosaccharide. The name comes from Greek（ σιαλοσ (sialos) 'saliva') this is a negatively charged ion that can make saliva produce a smooth feeling. It not only has the function of "inducing" invading bacteria, but also cognition is the transmitter of gangliosides, and is a part of the brain.
N-Acetylneuraminic acid (SA), known as "N-acetylneuraminic acid", is a naturally occurring carbohydrate. It was originally isolated from mucin of submandibular gland, hence its name. Sialic acids are usually present in the form of oligosaccharides, glycolipids or glycoproteins. Brain has the highest sialic acid content in human body. The content of sialic acid in brain gray matter is 15 times higher than that in liver, lung and other internal organs. The main food source of sialic acid is human milk, which is also found in milk, eggs and cheese.
Chinese Name: N-acetylneuraminic acid
English Name: N-acetylneuraminic acid
Alias name: sialic acid acetic newala acid N-acetylmannosamine pyruvate n-acetylsialic acid
More aliases: 5-acetamido-3,5-dioxy-d-glycoro-d-galactonulosonic acid o-sialic acid galactonulosonic acid lactamic acid Nana n-acetylsic acid
Molecular formula: c11h19no9
Molecular weight: 309.27
CAS No.: 131-48-6
MDL No.: mfcd00006620
EINECS No.: 205-023-1
RTECS No.:
BRN No.: 1716283
PubChem No.: 24890457
Acid physical property data of bird's nest
Character: colorless crystal.
Melting point (º C): 185-187 (decomposition)
Specific rotation (º, C = 2, in water): - 32
Solubility: soluble in water and methanol, slightly soluble in ethanol, insoluble in ether, acetone and chloroform.
Acute toxicity: Main irritating effect: on the skin: may cause inflammation. Above the eyes: may cause inflammation. Sensitization: no sensitization effect.
Ecological data of N-Acetylneuraminic acid
Water hazard level 1 (German regulation) (self assessment by list) the substance is slightly hazardous to water.
Do not allow undiluted or large quantities of products to come into contact with groundwater, waterways or sewage systems.
Do not discharge materials into the surrounding environment without government permission.
1. Molar refractive index: 65.66
2. Molar volume (cm3 / mol): 188.0
3. Isotonic specific volume (90.2k): 588.1
4. Surface tension (dyne / cm): 95.7
5. Polarizability (10-24cm3): 26.03
1. Reference value for hydrophobic parameter calculation (xlogp): - 3.5
2. Number of hydrogen bond donors: 7
3. Number of hydrogen bond receptors: 9
4. Number of rotatable chemical bonds: 5
5. Number of tautomers: 2
6. Topological molecular polar surface area (TPSA): 177
7. Number of heavy atoms: 21
8. Surface charge: 0
9. Complexity: 403
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 6
12. Number of indeterminate atomic stereocenters: 0
13. Determine the number of chemical bond steric centers: 0
14. Number of indeterminate chemical bond steric centers: 0
15. Number of covalent bond units: 1
In medicine, glycolipids containing sialic acid are called gangliosides, which play a very important role in the generation and development of the brain and nervous system. At the same time, animal experimental studies show that the decrease of ganglioside level is related to early malnutrition and reduced learning ability, and sialic acid supplementation can improve the learning behavior of animals. Adequate sialic acid supply may be particularly important for the normal development of brain function in low birth weight children. After the baby is born, the sialic acid in the breast milk is essential to ensure their normal development. The survey showed that the level of sialic acid in the mother's body decreased with time after delivery. Therefore, continuous intake of sufficient sialic acid during and after pregnancy can help maintain the sialic acid level in the body. Not only that, the content of sialic acid also has a significant correlation with the content of DHA, which indicates that it is very likely to be related to the brain structure and brain function development of infants, and both may be beneficial to early brain development.
Serum sialic acid assay (SA)
[reference value] 1.29 ～ 2.42mmol/l (40 ～ 75mg / dl) (nana-ald colorimetric method)
[conversion factor] mmol / L × 30.39= mg/dl，mg/dl × 0.0323= mmol/L
[clinical significance] sialic acid is N-acetylneuraminic acid or any derivative of its ester or its alcohol hydroxyl group. It is located at the end of the side chain of cell membrane glycoprotein. It is an important component of cell membrane surface receptors and increases in the occurrence of various inflammatory diseases and malignant tumors, such as lung cancer, gastric cancer, intestinal cancer, liver cancer and ovarian cancer.