The effect of Cnidium

Treat infertility

Cnidium can improve sex hormones, both male and female. It can treat both male and female infertility. "Compendium of Materia Medica" records that it can "warm the yang qi of the husband and help the yin qi of the woman". It can treat male sexual dysfunction, impotence and premature ejaculation. It can be used together with Epimedium and Antler Tablets, and it can also treat female sexual dysfunction and infertility. It can be used with Morinda officinalis and Eucommia. If the internal fire is large, it can be used together with Habitat and Ophiopogon to balance cold and heat.

Anti-allergy

Cnidium has anti-allergic effect and can treat allergic diseases, such as eczema, prurigo, urticaria, etc. However, these skin diseases are mainly based on blood heat and damp heat. Therefore, Cnidium needs to be combined with anti-allergic and anti-allergic effects for clearing heat and cooling blood. The same use of traditional Chinese medicine, such as scutellaria baicalensis, Danpi, raw rehmannia etc.

 Cnidium can resist allergies and relax smooth muscle spasm, so it can treat asthma. It is equivalent to Epimedium and Scutellaria. The effect of Cnidium monnieri in treating asthma has not attracted clinical attention.

Anti-asthmatic and expectorant

The total coumarin of Cnidium has the antispasmodic effect of directly expanding the bronchus, which may be achieved by excitating p receptors. The total coumarin of Cnidium has a strong expectorant effect. Studies have shown that: Cnidium has a strong bronchiectasis effect, and Osthole can increase the guinea pig lung perfusion flow, and its effect is stronger than aminophylline. The total coumarins of Cnidium biloba can be administered to guinea pigs to prolong the time of asthma attacks caused by histamine phosphate and acetylcholine chloride.

In vitro experiments have shown that the total coumarin of Cnidium has a strong antagonistic effect on isolated guinea pig tracheal contraction induced by histamine. The above effects can be blocked by Propranolol without affecting the heart rate and blood pressure of anesthetized animals, suggesting that the total coumarin of Cnidium may selectively excite the β2 receptors on the bronchial smooth muscles, resulting in antispasmodic and antiasthmatic effects. The total coumarin of Cnidium sylvestris can be given to mice by gavage, which can significantly increase the excretion of phenol red, indicating that the product has a strong expectorant effect.

Kill Trichomonas vaginalis

In vitro experiments of this product extract have the effect of killing Trichomonas vaginalis and have inhibitory effects on various fungi.

Traditionally, it is used to treat trichomoniasis, mold infections, etc., and external treatment is mainly used.

Antifungal effect

Osthole, bergamot lactone and isoxifrin have strong activity against Trichophyton and Trichophyton mentagrophytes in vitro; Xanthotoxin has significant antifungal effect.

Anti-arrhythmia

The water extract of Cnidium monnieri has a preventive effect on chloroform-induced ventricular fibrillation in mice, calcium chloride-induced ventricular fibrillation in rats, and ornithine-induced arrhythmia in rats, and has obvious therapeutic effects on the latter.

Local anesthesia

The water extract of Cnidium monnieri has a blocking anesthetic effect on the isolated sciatic nerve of toads; it hasan infiltration anesthetic effect on guinea pigs, and can be enhanced by epinephrine hydrochloride; it has spinal anesthesia effect on rabbits, but has no surface anesthesia on rabbit cornea effect. It can also significantly prolong the sleep time of pentobarbital sodium.

Anti-allergic

Osthole can strongly inhibit the passive skin allergic reaction in mice, and has a protective effect on the overall guinea pig histamine wheezing. It has obvious effect on the contraction of the isolated ileum of guinea pigs caused by slow-reacting substances and the Schultz-Dzle reaction of the isolated guinea pig ileum Antagonistic and blocking effects, and can inhibit the degranulation of rat abdominal mast cells. The above effects are all dose-dependent.

Anti-mutagenic

The water extract of Cnidium monnieri, through the exchange of sister chromatid of Ames and in vitro cells, chromosomal aberrations in bone marrow cells of living mice and micronucleus test of polychromatic erythrocytes showed that the drug has a strong anti-mutagenic effect.

Killer

Putting Cnidium in the sewage can kill the larvae.

Killing effect on sperm

Mix the Cnidium monnieri extract powder into 20%, 25%, 30%, 35%, and 40% suspensions with physiological saline, and place them at room temperature for 48 hours, 200 rpm / separation for 10 minutes, and filter the supernatant. Store at 4℃.

Observing the spermicidal effect with the drug, it can be seen that the spermicidal effect increases with the increase of the concentration of the drug solution. The minimum effective concentration to inhibit human sperm within 20 seconds is 30%. Each milliliter of semen is mixed with different doses of Cnidium monnieri extract powder. The minimum effective dose for inhibiting sperm motility is 250-300mg. Experiments show that Cnidium may become a vaginal contraceptive.