Publish Time: 2020-06-17 Origin: Site
As we age, men’s demand for ingredients and products that support healthy aging continues to increase. Market research company Technavio predicts in a 2019 report that by 2023, the compound annual growth rate of the global anti-aging ingredients market will reach 5%. The increasing interest of men in anti-aging products will create new market opportunities for new ingredients and new products. These ingredients mainly solve problems such as prostate disease, sexual dysfunction and muscle wasting.
Previous studies have confirmed the positive effects of maca (Lepidiummeyenii) roots on humans, animals, and sperm counts, and new clinical trials are evaluating its effectiveness as strength enhancers, vitality enhancers, and sexual behavior aids.
A randomized, double-blind, placebo-controlled clinical trial evaluated the Peruvian Maca’s patented ingredient Lepidamax (manufactured by Nutrition21) on 47 healthy subjects (22 men and 25 women) aged 18-53 years in these three Aspects.
Throughout the trial, participants were randomly assigned to take 700 mg of Lepidamax 3 times a day (n=25) or placebo (n=22). All participants performed body composition and grip strength assessments on the first and 28th days. At the same time, all participants completed the emotional state questionnaire and sexual function Derogatis interview on the first day and the 28th day.
Compared with the placebo group, the male participants in the treatment group had a statistically significant increase in grip strength and sexual behavior, and a statistically significant decrease in fatigue. The study authors said that maca root may reduce fatigue in healthy men, increase strength, and improve sexual function.
The driving force of the male health aging market is that consumers want to stay healthy in old age. As life expectancy increases, more and more older men will seek products to help them live better. Consumers are not only to cope with aging, but also to live the most ideal life at any age, which is why we see that there are many sports nutrition and vitality products for elderly men on the market.
Fenugreek extract maintains strength
Fenugreek extract (Trigonella foenum-graecum) continues to show positive results in clinical trials as a fitness supplement. Older men occupy a huge and growing market share in the market of vital nutritional supplements. The health issues they are most concerned about are their flexibility and ability to live independently. Such consumers are looking for supplements that can help them stay healthy. .
Inconvenience in movement is one of the most concerns of the elderly in the United States. The challenges and opportunities faced by the elderly are not encountered by previous generations. 20% of men over the age of 60 have testosterone levels lower than normal, and this percentage rises to 50% among men over the age of 80. This is due to the binding of sex hormone binding globulin (SHBG) to testosterone, and reduces the levels of total testosterone and free testosterone over time.
Low testosterone levels can lead to decreased muscle mass, decreased bone density and decreased libido. Decreased age-related testosterone can also lead to slower metabolism and increased inflammation, which is why testosterone-enhancing products are becoming more popular among the elderly.
A randomized, clinical trial in 2016 evaluated the effectiveness of Gencor's brand fenugreek extract Testofen on 98 menopausal healthy and physically active male patients between the ages of 43 and 70 years with reduced menopausal symptoms. Participants were randomly assigned to take 300 mg (n=35) or 600 mg (n=31) Testofen per day, or take an equivalent amount of placebo (n=32) for a duration of 12 weeks. The researchers evaluated the participants' muscle strength, aerobic endurance, body composition, body weight, total testosterone, and functional threshold ability after 12 weeks.
The results found that compared with the placebo group, the 600 mg supplementation subjects had a statistically significant increase in lower body strength, functional threshold capacity and total testosterone levels. Compared with the placebo group and the 300 mg group, the 600 mg group lost weight and the percentage of lean body mass increased. The idea of taking supplements to help healthy aging is becoming more and more acceptable for elderly men, especially sexual health supplements, which are increasingly popular among the elderly.
At present, products for improving male sexual health are everywhere. The general misconception that the elderly no longer have sex has long been unknown. Although sex life usually decreases with age, a study published in 2008 found that more than half of people aged 65 to 74 continue to maintain sex life.
New mechanism of Tongkat Ali's sexual health promotion
Tongkat Ali (Eurycomalongifolia) is a sexual enhancer. In the past, it mainly focused on its ability to increase testosterone and sperm count. But now, new research shows that it can also interact with enzymes to promote normal erectile function.
An in vitro chromatography study conducted in 2019 revealed the important mechanism behind LJ100, which is the Tongkat Ali supplement brand produced by HP Ingredients. The researchers found that the extract can successfully inhibit up to 81% of the activity of kinase II (ROCK-II). Tongkat Ali's traditional use as a male sexual dysfunction may be partly due to the inhibitory potential of ROCK-II.
Research on LJ100 has found other mechanisms of action that may explain its other health effects. The company’s 15 clinical trials on LJ100 have shown that Tongkat Ali can also increase sexual satisfaction by increasing dopamine, by inhibiting phosphodiesterase 5 (PDE-5), arginase and angiotensin I converting enzyme ( ACE) to improve vasodilation.
Human clinical studies also support LJ100 to reduce reactive oxygen species, thereby increasing the nitric oxide cGMP signaling pathway to maintain more difficult erections and increase alpha pheromones, thereby improving libido, sexual communication, and sexual behavior. The male health aging industry has been vigorously promoting testosterone alternatives. The positioning of LJ100 is different. On the contrary, it promotes the awakening of the dormant testosterone production system and the endogenous release of free testosterone.
New role in the market, French pine bark
The results of a new clinical study show that the link between blood health and male sexual health is becoming more and more obvious. A randomized, double-blind, placebo-controlled clinical study in 2019 was conducted to evaluate the effect of Pycnogenol extract from French marine pine bark on blood lipids and erectile function. 53 men with an average age of 49 years showed normal testosterone levels and met the diagnostic criteria for IIEF-5 erectile dysfunction.
Participants were randomly assigned to take Pycnogenol 120 mg (n=32) or placebo (n=21) daily for three months. The components of Pycnogenol were comorbid diabetes group (15 cases) and non-complicated diabetes group (17 cases). The placebo group was also divided into subgroups with diabetes (n=10) or without diabetes (n=11).
All participants were assessed by the IIEF-5 questionnaire at baseline, monthly during the trial, and one month after the final dose. Participants also provided blood samples at baseline, one month after the start of the trial, and one month after the end of the trial. Participants' serum samples were used to detect cholesterol, high-sensitivity C-reactive protein, glucose, and triacylglycerol.
After taking Pycnogenol for 3 consecutive months, the erectile function of both groups of patients improved significantly. Diabetes patients' IIEF-5 score increased by 45%, which represents an improvement from severe to moderate erectile dysfunction. The scores of participants without diabetes increased by 22%, but remained within the range of moderate severity, and the placebo group's IIEF-5 score did not change statistically.
Pycnogenol can promote the production of nitric oxide, thereby supporting blood health, which explains the effect of Pycnogenol on erectile function. Erectile dysfunction may be an indicator of potential health problems, such as heart disease or diabetes, which is why it is important to study the effectiveness of erectile function health supplements in people with these diseases.
A large number of studies have shown that Pycnogenol can promote the production of nitric oxide, thereby improving erectile function, and other studies have also found that Pycnogenol can improve the microcirculation and blood sugar levels of diabetic patients. But this new study is particularly interesting because patients with diabetes have a higher incidence of erectile dysfunction.
Other health ingredients
Pumpkin Seed Protein
A public trial conducted in 2019 against 60 men with benign prostatic hyperplasia found that men who consume 500 mg of Go-Less daily, the brand of pumpkin seed extract produced by Israel’s Huachen, can reduce IPSS by 30% after 12 weeks Score and significantly reduce BPH symptoms. Consumers’ demand for natural remedies is increasing and they are considering abandoning OTC products. They are looking for healthy aging ingredients that can improve the quality of life. Saw palmetto price fluctuations and adulteration issues open up opportunities for new alternatives.
Lycopene
Although most sexual health supplements target older men, research shows that young men can also benefit from such products. In March 2020, a randomized, placebo-controlled trial of 56 men between the ages of 18 and 30 found that lycopene (n=28) was taken for 12 weeks compared to placebo (n=28) After that, taking 14 mg of lycopene per day will improve the vitality and morphology of sperm. The study used a proprietary lycopene extract LactoMato, produced by Sibelius Natural Products in the United Kingdom.
Lycopene & Carotenoids
Maintaining healthy blood pressure levels is the number one priority for men over 50. New research shows that lycopene and carotenoids can maintain healthy blood pressure. In a clinical trial conducted by Leconrad in 2019, researchers found that, compared with placebo (n=26), Lycomato (n=26), a tomato nutrition complex of Leconrad brand, can help reduce hypertension in men after 4 weeks. blood pressure.
With the increasing trend of global aging, men are also a group worthy of attention, especially elderly men. They often have obvious needs for muscle gain, improved sexual function, and physical flexibility. The needs of elderly women may be more concentrated on anti-aging, external skin maintenance and physical flexibility. Therefore, when developing anti-aging products, we should combine different consumer groups to develop corresponding products in a targeted manner.